Hiram College
Cara Constance, Ph.D. Photo

Cara Constance, Ph.D.

Associate Professor of Biology

Dr. Cara Constance is Associate Professor and is currently serving as Chair of the Department of Biology. She also serves as a premedical advisor on the Health Sciences board, and advises students in the Neuroscience major. She is also a co-coordinator of the Hiram College FrogWatch USA Chapter.

Dr. Constance’s teaching interests include molecular and cellular biology, human genetics, chronobiology, as well as introductory and elective courses in the biology major. She also regularly teaches interdisciplinary courses, ranging in topics from sleep to a study abroad course in Japan.


  • B.A., Hiram College
  • PH.D., University of Virginia

Research Interests

My research focuses on understanding the molecular basis of biological rhythms. Virtually all organisms have adapted to life on earth by having an internal timer that controls rhythmic behavioral, biochemical, and physiological processes, and confers a circadian period of about a day. My primary research interest is to determine how the molecules that comprise the central clock mechanism ultimately lead to regulation of rhythmic behaviors.

Selected Publications

  • Lois M. Banta, Erica J. Crespi, Ross H. Nehm, Jodi A. Schwarz, Susan Singer, Cathryn A. Manduca, Eliot C. Bush, Elizabeth Collins, Cara M. Constance, Derek Dean, David Esteban, Sean Fox, John McDaris, Carol Ann Paul, Ginny Quinan, Kathleen M. Raley-Susman, Marc L. Smith, Christopher Wallace, Ginger Withers and Lynn Caporale. (2012). Integrating genomics research throughout the undergraduate curriculum: A collection of inquiry-based genomics lab modules. Cell Biology Education- Life Sciences Education. 11(3): 203-208..
  • Kudo T, Loh DH, Kuljis D, Constance C, Colwell CS. (2011). Fast delayed rectifier potassium current: critical for input and output of the circadian system. J Neurosci. Feb 23;31(8):2746-55.
  • Kim SM, Power A, Brown TM, Constance CM, Coon SL, Nishimura T, Hirai H, Cai T, Eisner C, Weaver DR, Piggins HD, Klein DC, Schnermann J, Notkins AL.(2009). Deletion of the secretory vesicle proteins IA-2 and IA-b disrupts circadian rhythms of cardiovascular and physical activity. FASEB J. Sep;23(9):3226-32.
  • Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN*, Debruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR. (2009). Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. Jul;29(14):3853-66.
  • Constance, C.M., Fan J-Y, Preuss F., Green C.B., Price J.L. (2005) The circadian clock-containing photoreceptor cells in Xenopus laevis express several isoforms of casein kinase I. Brain Res. Mol. Brain Res. May 20;136(1-2):199-211.
  • Constance, C.M., Green, C.B., Tei, H., and Block, G.D. (2002) Bulla gouldiana period Exhibits Unique Regulation at the mRNA and Protein Levels. J Biol. Rhythms 17 (5) 413-427.

Fun Facts

  • I have organized the Hope for Happiness Walk to Prevent Suicide at Hiram College to raise awareness about suicide and depression and fight the stigma of mental illness.
  • I am an avid reader of mystery novels, love to do primitive camping, and have 3 dogs, 3 cats, 4 frogs, and 2 hermit crabs sharing my home with my family of my spouse and 3 kids.

Additional Links

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